The principle of the Luciole System is based on the absorption of certain part of the light spectrum (called Near InfraRed due to its proximity to the red light) by hemoglobin (the oxygen carrier of the blood). The signal propagated within the brain needs to be analyzed. Even though the scientific principle has been known for more than 60 years, the signal treatment and the propagation of the Near Infrared Light was only recently fully understood.


Luciole Medical’s technology is based on extensive data insights from inside the brain.

Features of Luciole Medical’s technology

  • Luciole’s proprietary algorithm isolates oxygen saturation levels from signals received at two different depths in the brain
  • Four different light wavelengths from lasers probe different brain compartments to enhance readout specificity and accuracy of oxygenation status
  • Luciole is the only company with patented technology that measures cerebral blood flow based on well-established and validated method used in heart analysis
  • Data obtained from inside the brain (with probe) validates measurements taken in parallel from outside the skull (with patch)
Measurement depth

Medical Need

Medical Need: * (1) Slater JP., et al., (2009) Ann. Thorac. Surg. (2) Subramanian B., et al., (2016) Anesth. Analg.

Indications Where Brain Monitoring Represents High Medical Need:

  • Cardiac surgery
  • Orthopedic and spine surgery
  • Extra Corporeal Membrane Oxygenation
Neurocritical care
  • Subarachnoid hemorrhage
  • Traumatic Brain Injury
  • Severe stroke
  • Cardiac arrest
  • Surgery
  • Traumatic Brain Injury
  • Extra Corporeal Membrane Oxygenation
Sleep apnea
  • Diagnostic
  • Treatment monitoring
  • Post surgery apnea
Medical Wearable
  • Brain health monitoring


M. Seule, C. Sikorski, O. Sakowitz, G. von Campe, E. Santos, B. Orakcioglu, A. Unterberg, E. Keller, (2016), Evaluation of a New Brain Tissue Probe for Intracranial Pressure, Temperature, and Cerebral Blood Flow Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care, Volume 25, Issue 2, pp 193–200

E. Keller, J. Froehlich, D. Baumann, C. Böcklin, C. Sikorski, M. Oberle, M. Muser, (2015), Detection of Delayed Cerebral Ischemia (DCI) in Subarachnoid Haemorrhage Applying Near-Infrared Spectroscopy: Elimination of the Extracerebral Signal by Transcutaneous and Intraparenchymatous Measurements in Parallel, in Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement Volume 120, pp 243-247

C. Böcklin, D. Baumann, F. Stuker, J. Fröhlich, (2015), Mixing formula for tissue-mimicking silicone phantoms in the near infrared, J. Phys. D: Appl. Phys. 48 (10)

C. Böcklin, D. Baumann, J. Fröhlich, (2014), New approach for absolute fluence distribution calculations in Monte Carlo simulations of light propagation in turbid media, Journal of Applied Physics, Vol. 115, Issue 6, pp.DOI: 10.1063/1.4865171

E.Keller, J. Fröhlich, C. Muroi, C. Sikorski, M. Muser, (2011), Neuromonitoring in intensive care: A new brain tissue probe for combined monitoring of intracranial pressure (ICP), cerebral blood flow (CBF) and oxygenation, Acta Neurochirurgica (Supplement), Vol. 110, Issue 2, pp.217-20

N. F. Newman et al., (2001), Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery, The New England Journal of Medicine, Vol. 344, No. 6, pp. 395-402


Luciole Medical has exclusive rights to its platform technology and has its own patents for the advanced software algorithms.

List of selected patents of the different patent families:

  • Probe and apparatus for measuring cerebral hemodynamics and oxygenation (EP1301119 (B1))
  • Device for measuring blood-flow in an organ (EP1464276 (B1))
  • Device for diagnosis and /or therapy of physiological characteristics of a selected portion of the body by optical reflectance or optical transmission (EP2168475 (B1))
  • Measuring device for measuring cerebral parameters (US9668681 (B2))
  • Measuring device for determining cerebral parameters, pending
  • Measurement System and Method for Measuring Parameters in a Body Tissue, pending