The principle of the Luciole System is based on the absorption of certain part of the light spectrum (called Near InfraRed due to its proximity to the red light) by hemoglobin (the oxygen carrier of the blood). The signal propagated within the brain needs to be analyzed. Even though the scientific principle has been known for more than 60 years, the signal treatment and the propagation of the Near Infrared Light was only recently fully understood.
Luciole Medical’s technology is based on extensive data insights from inside the brain.
M. Seule, C. Sikorski, O. Sakowitz, G. von Campe, E. Santos, B. Orakcioglu, A. Unterberg, E. Keller, (2016), Evaluation of a New Brain Tissue Probe for Intracranial Pressure, Temperature, and Cerebral Blood Flow Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care, Volume 25, Issue 2, pp 193–200
E. Keller, J. Froehlich, D. Baumann, C. Böcklin, C. Sikorski, M. Oberle, M. Muser, (2015), Detection of Delayed Cerebral Ischemia (DCI) in Subarachnoid Haemorrhage Applying Near-Infrared Spectroscopy: Elimination of the Extracerebral Signal by Transcutaneous and Intraparenchymatous Measurements in Parallel, in Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement Volume 120, pp 243-247
C. Böcklin, D. Baumann, F. Stuker, J. Fröhlich, (2015), Mixing formula for tissue-mimicking silicone phantoms in the near infrared, J. Phys. D: Appl. Phys. 48 (10)
C. Böcklin, D. Baumann, J. Fröhlich, (2014), New approach for absolute fluence distribution calculations in Monte Carlo simulations of light propagation in turbid media, Journal of Applied Physics, Vol. 115, Issue 6, pp.DOI: 10.1063/1.4865171
E.Keller, J. Fröhlich, C. Muroi, C. Sikorski, M. Muser, (2011), Neuromonitoring in intensive care: A new brain tissue probe for combined monitoring of intracranial pressure (ICP), cerebral blood flow (CBF) and oxygenation, Acta Neurochirurgica (Supplement), Vol. 110, Issue 2, pp.217-20
N. F. Newman et al., (2001), Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery, The New England Journal of Medicine, Vol. 344, No. 6, pp. 395-402
Luciole Medical has exclusive rights to its platform technology and has its own patents for the advanced software algorithms.