Technology

The principle of the Luciole System is based on the absorption of certain part of the light spectrum (called Near InfraRed due to its proximity to the red light) by hemoglobin (the oxygen carrier of the blood). The signal propagated within the brain needs to be analyzed. Even though the scientific principle has been known for more than 60 years, the signal treatment and the propagation of the Near Infrared Light was only recently fully understood.

Innovation

Luciole Medical’s technology is based on extensive data insights from inside the brain.

Features of Luciole Medical’s technology

  • Luciole’s proprietary algorithm isolates oxygen saturation levels from signals received at two different depths in the brain
  • Four different light wavelengths from lasers probe different brain compartments to enhance readout specificity and accuracy of oxygenation status
  • Luciole is the only company with patented technology that measures cerebral blood flow based on well-established and validated method used in heart analysis
  • Luciole is the only company able to show that data obtained outside the skull (with patch) are correlated with measurements taken in parallel inside the brain (with probe)
Measurement depth

Medical Need

Medical Need: * (1) Slater JP., et al., (2009) Ann. Thorac. Surg. (2) Subramanian B., et al., (2016) Anesth. Analg.

Indications Where Brain Monitoring Represents High Medical Need:

Anesthesia
  • Cardiac surgery
  • Orthopedic and spine surgery
  • Extra Corporeal Membrane Oxygenation
Neurocritical care
  • Subarachnoid hemorrhage
  • Traumatic Brain Injury
  • Severe stroke
  • Cardiac arrest
Pediatric
  • Surgery
  • Traumatic Brain Injury
  • Extra Corporeal Membrane Oxygenation
Sleep apnea
  • Diagnostic
  • Treatment monitoring
  • Post surgery apnea
Medical Wearable
  • Brain health monitoring

Publications

Maximilian Oremek, Paul Nowotny, Sebastian Zimmer, Atsushi Sugiura, Leonie Weinhold, Juerg Froehlich, Martin Soehle, André Diedrich, Marcus Thudium, (2025) Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique. J Clin Med. 2025 Jun 17;14(12):4317.

Maximilian J Oremek, Anna von Bargen, Jan-Niklas Hoenemann, André Diedrich, Juerg Froehlich, Mohammed Banat, Philipp Krausewitz, Martin Soehle, Marcus Thudium, (2024), Regional cerebral blood flow is compromised during robotic surgery in the Trendelenburg position, but not during surgery in the beach chair position: an observational study. Br J Anaesth. 2024 Oct;133(4):896-898.

Jan F Willms, Jens M Boss, Shufan Huo, Stefan Wolf, Laura P Westphal, Stefan Y Bögli, Corinne Inauen, Dirk Baumann, Jürg Fröhlich, Emanuela Keller, (2024), Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage. J. Neuroscience Methods. 2024 Jun:406:110113. 

Gagan Narula, Jens Boss, Marko Seric, Daniel Baumann, Joan P Salles, Jürg Fröhlich, Dirk Baumann, Emanuela Keller, Jan Willms, (2024), Evaluation of machine learning algorithms for noninvasive intracranial pressure estimation using near infrared spectroscopy as a covariate. Technology Health Care, 2024;32(2):937-949.

M. Seule, C. Sikorski, O. Sakowitz, G. von Campe, E. Santos, B. Orakcioglu, A. Unterberg, E. Keller, (2016), Evaluation of a New Brain Tissue Probe for Intracranial Pressure, Temperature, and Cerebral Blood Flow Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care, Volume 25, Issue 2, pp 193–200

E. Keller, J. Froehlich, D. Baumann, C. Böcklin, C. Sikorski, M. Oberle, M. Muser, (2015), Detection of Delayed Cerebral Ischemia (DCI) in Subarachnoid Haemorrhage Applying Near-Infrared Spectroscopy: Elimination of the Extracerebral Signal by Transcutaneous and Intraparenchymatous Measurements in Parallel, in Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement Volume 120, pp 243-247

C. Böcklin, D. Baumann, F. Stuker, J. Fröhlich, (2015), Mixing formula for tissue-mimicking silicone phantoms in the near infrared, J. Phys. D: Appl. Phys. 48 (10)

C. Böcklin, D. Baumann, J. Fröhlich, (2014), New approach for absolute fluence distribution calculations in Monte Carlo simulations of light propagation in turbid media, Journal of Applied Physics, Vol. 115, Issue 6, pp.DOI: 10.1063/1.4865171

E.Keller, J. Fröhlich, C. Muroi, C. Sikorski, M. Muser, (2011), Neuromonitoring in intensive care: A new brain tissue probe for combined monitoring of intracranial pressure (ICP), cerebral blood flow (CBF) and oxygenation, Acta Neurochirurgica (Supplement), Vol. 110, Issue 2, pp.217-20

N. F. Newman et al., (2001), Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery, The New England Journal of Medicine, Vol. 344, No. 6, pp. 395-402

Patents

Luciole Medical has exclusive rights to its platform technology and has its own patents for the advanced software algorithms.

List of selected patents of the different patent families:

  • Probe and apparatus for measuring cerebral hemodynamics and oxygenation (EP1301119 (B1))
  • Device for measuring blood-flow in an organ (EP1464276 (B1))
  • Device for diagnosis and /or therapy of physiological characteristics of a selected portion of the body by optical reflectance or optical transmission (EP2168475 (B1))
  • Measuring device for measuring cerebral parameters (US9668681 (B2))
  • Measuring device for determining cerebral parameters, pending
  • Measurement System and Method for Measuring Parameters in a Body Tissue, pending